Hummingbirds are important pollinators, though nectar-stealing carpenter bees and verdins have been found to effectively pollinate. Antelope ground squirrels feed on flowers and seeds that fall to the ground.
Native people, including the Seri, Cahuilla, Yavapai, Pima, Tohono and Hiá ced O’ohdam also consumed the flowers and nectar or used the flowers to flavor water. The Cahuilla used protein-rich seeds to make flour for mush or cakes In both past and modern times, ocotillo stems are used for fencing (sometimes as a living fence), house walls, and ramada roofs.